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In vitro and in vivo activities of phosphate derivatives of 9-(1,3-dihydroxy-2-propoxymethyl)-guanine against cytomegaloviruses

✍ Scribed by Arit E. Duke; Donald F. Smee; Marlene Chernow; Richard Boehme; Thomas R. Matthews


Book ID
118391812
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
471 KB
Volume
6
Category
Article
ISSN
0166-3542

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Interaction of 9-(1,3-dihydroxy-2-propox
✍ Donald F. Smee πŸ“‚ Article πŸ“… 1985 πŸ› Springer 🌐 English βš– 504 KB

The acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) is a potent inhibitor of human cytomegalovirus in vitro and in vivo. In order to investigate the phosphorylation of DHPG to the monophosphate and identify the enzyme responsible, attempts were made to isolate DHPG kinase from cal