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Synthesis and antiherpes virus activity of phosphate and phosphonate derivatives of 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine

โœ Scribed by Prisbe, Ernest J.; Martin, John C.; McGee, Danny P. C.; Barker, Molly F.; Smee, Donald F.; Duke, Arit E.; Matthews, Thomas R.; Verheyden, Julien P. H.


Book ID
118173281
Publisher
American Chemical Society
Year
1986
Tongue
English
Weight
674 KB
Volume
29
Category
Article
ISSN
0022-2623

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โœ Joanne Rush; John Mills ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 458 KB

Both the nucleoside analog 9[(1,3-dihydroxy-2-propoxy)methyl]guanine (ganciclovir; DHPG) and the polyamine synthesis inhibitor difluoromethylornithine (DFMO) have been reported to inhibit replication of cytomegalovirus (CMV) in vitro. In these studies, DHPG inhibited human CMV replication at concent