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Synthesis of the 7-deaza and 5-aza-7-deaza purine analogs of the antiherpes agent 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine (DHPG)

✍ Scribed by Danny P. C. Mcgee; John C. Martin; Julien P. H. Verheyden


Book ID
112127953
Publisher
Journal of Heterocyclic Chemistry
Year
1985
Tongue
English
Weight
344 KB
Volume
22
Category
Article
ISSN
0022-152X

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The Donor-Acceptor-Acceptor Purine Analo
✍ Johannes J. Voegel; Michael M. Altorfer; Steven A. Benner πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 German βš– 656 KB

A new synthesis is reported for 4-aminoimidazo[l,2-~]-1,3,5-triazin-2( IH)-one ( = 5-aza-7-deaza-isoguanosine; S), a purine analog that, when incorporated into an oligonucleotide chain, presents a H-bond donor-acceptor-acceptor pattern to a complementary pyrimidine analog. A protected ribose derivat