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Induction of dominant lethal mutations in male mice by fosfestrol

✍ Scribed by U. H. Ehling

Publisher: Springer-Verlag
Year: 1978
Tongue: English
Weight: 342 KB
Volume: 42
Category: Article
ISSN: 0340-5761
DOI: 10.1007/bf00353708

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✦ Synopsis

Using the dominant lethal assay, the ability of fosfestrol, a diethylstilboestrol derivate, to induce mutations in male mice was tested and confirmed. Up to 300 mg/kg of fosfestrol the induction of mutations occurs exclusively in spermatozoa. A dose of 600 mg/kg of fosfestrol induces dominant lethal mutations up to 10 days posttreatment. The majority of induced dominant lethal mutations in all dose groups are expressed as loss after implantation.

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