Dominant lethal mutations are due to chromosome aberrations as demonstrated by analysis of first cleavage. With a sample size of 40-45 mice per dose the induction of dominant lethal mutations by 10 mg/kg of methyl methanesulfonat (MMS) can be detected in spermatids in the mating interval 9-12 days p
Trichloroethylene vapours do not produce dominant lethal mutations in male mice
โ Scribed by Renate Slacik-Erben; R. Roll; G. Franke; H. Uehleke
- Publisher
- Springer-Verlag
- Year
- 1980
- Tongue
- English
- Weight
- 400 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0340-5761
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Using the dominant lethal assay, the ability of fosfestrol, a diethylstilboestrol derivate, to induce mutations in male mice was tested and confirmed. Up to 300 mg/kg of fosfestrol the induction of mutations occurs exclusively in spermatozoa. A dose of 600 mg/kg of fosfestrol induces dominant lethal
Calcium cyclamate, an artificial sweetener, was studied for its effectiveness in inducing transmissible chromosomal aberrations in germ cells of male mice. Both the dominant-lethal and the heritable translocation tests were carried out following daily treatment (on weekdays) of males by oral intubat