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No evidence found for induction of dominant lethal mutations and heritable translocations in male mice by calcium cyclamate

✍ Scribed by Katherine T. Cain; Carolyn V. Cornett; Nestor L. A. Cacheiro; Lori A. Hughes; James G. Owens; Walderico M. Generoso

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 447 KB
Volume: 11
Category: Article
ISSN: 0893-6692
DOI: 10.1002/em.2850110206

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✦ Synopsis

Calcium cyclamate, an artificial sweetener, was studied for its effectiveness in inducing transmissible chromosomal aberrations in germ cells of male mice. Both the dominant-lethal and the heritable translocation tests were carried out following daily treatment (on weekdays) of males by oral intubation with the maximum tolerated dose for 6 weeks. Calcium cyclamate is negative in both tests; therefore, there is no evidence of induced chromosome breakage and exchange.

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