Calcium cyclamate, an artificial sweetener, was studied for its effectiveness in inducing transmissible chromosomal aberrations in germ cells of male mice. Both the dominant-lethal and the heritable translocation tests were carried out following daily treatment (on weekdays) of males by oral intubat
✦ LIBER ✦
Comparative investigations on the chemical induction of point mutations and dominant lethal mutations in mice
✍ Scribed by P. Propping; G. Röhrborn; W. Buselmaier
- Publisher
- Springer
- Year
- 1972
- Tongue
- English
- Weight
- 722 KB
- Volume
- 117
- Category
- Article
- ISSN
- 1617-4615
No coin nor oath required. For personal study only.
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The molecular nature of lethal and semilethal mutations in the Pgd locus of D. melanogaster coding for 6-phosphogluconate dehydrogenase (6PGD) was studied. All the 11 mutations affect the structural gene of the Pgd locus: 3 semilethal mutations resulted in altered 6PGD molecules with decreased catal