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Induction of dominant lethal mutations by Ascaris trypsin inhibitor in male mice

✍ Scribed by Joanna Blaszkowska


Book ID
113875600
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
206 KB
Volume
29
Category
Article
ISSN
0890-6238

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Induction of dominant lethal mutations i
✍ U. H. Ehling πŸ“‚ Article πŸ“… 1978 πŸ› Springer-Verlag 🌐 English βš– 342 KB

Using the dominant lethal assay, the ability of fosfestrol, a diethylstilboestrol derivate, to induce mutations in male mice was tested and confirmed. Up to 300 mg/kg of fosfestrol the induction of mutations occurs exclusively in spermatozoa. A dose of 600 mg/kg of fosfestrol induces dominant lethal