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Induction of dominant lethal mutations by alkylating agents in male mice

โœ Scribed by U.H. Ehling; R.B. Cumming; H.V. Malling


Book ID
118952312
Publisher
Elsevier Science
Year
1968
Tongue
English
Weight
733 KB
Volume
5
Category
Article
ISSN
0027-5107

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๐Ÿ“œ SIMILAR VOLUMES


Induction of dominant lethal mutations i
โœ U. H. Ehling ๐Ÿ“‚ Article ๐Ÿ“… 1978 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 342 KB

Using the dominant lethal assay, the ability of fosfestrol, a diethylstilboestrol derivate, to induce mutations in male mice was tested and confirmed. Up to 300 mg/kg of fosfestrol the induction of mutations occurs exclusively in spermatozoa. A dose of 600 mg/kg of fosfestrol induces dominant lethal

Dominant lethal mutations in male mice
โœ U. H. Ehling ๐Ÿ“‚ Article ๐Ÿ“… 1977 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 648 KB

Dominant lethal mutations are due to chromosome aberrations as demonstrated by analysis of first cleavage. With a sample size of 40-45 mice per dose the induction of dominant lethal mutations by 10 mg/kg of methyl methanesulfonat (MMS) can be detected in spermatids in the mating interval 9-12 days p