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467 Induction of dominant lethal mutations in male mice by perezone

✍ Scribed by G. Chamorro; L. Garduño-Siliciano; M. Salazar


Book ID
119538236
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
58 KB
Volume
144
Category
Article
ISSN
0378-4274

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Induction of dominant lethal mutations i
✍ U. H. Ehling 📂 Article 📅 1978 🏛 Springer-Verlag 🌐 English ⚖ 342 KB

Using the dominant lethal assay, the ability of fosfestrol, a diethylstilboestrol derivate, to induce mutations in male mice was tested and confirmed. Up to 300 mg/kg of fosfestrol the induction of mutations occurs exclusively in spermatozoa. A dose of 600 mg/kg of fosfestrol induces dominant lethal

Dominant lethal mutations in male mice
✍ U. H. Ehling 📂 Article 📅 1977 🏛 Springer-Verlag 🌐 English ⚖ 648 KB

Dominant lethal mutations are due to chromosome aberrations as demonstrated by analysis of first cleavage. With a sample size of 40-45 mice per dose the induction of dominant lethal mutations by 10 mg/kg of methyl methanesulfonat (MMS) can be detected in spermatids in the mating interval 9-12 days p