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Impact of age on epidermal growth factor receptor mutation in lung cancer

โœ Scribed by Ueno, Tsuyoshi; Toyooka, Shinichi; Suda, Kenichi; Soh, Junichi; Yatabe, Yasushi; Miyoshi, Shinichiro; Matsuo, Keitaro; Mitsudomi, Tetsuya

Book ID
117989185
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
402 KB
Volume
78
Category
Article
ISSN
0169-5002

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Somatic mutations of epidermal growth fa
Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers
โœ Hisayuki Shigematsu; Adi F. Gazdar ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 540 KB

Somatic mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers have generated enormous interest, because they predict for sensitivity to TK inhibitors (TKIs). While mutational status is of great importance in determining response to TKIs, it