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Synchronous Primary Lung Cancer and Epidermal Growth Factor Receptor Mutation

โœ Scribed by Edmond S.K. Ma; Paul N.M. Cheng; Chris L.P. Wong; Anthony P.C. Yim


Book ID
113472398
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
938 KB
Volume
90
Category
Article
ISSN
0003-4975

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Somatic mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers have generated enormous interest, because they predict for sensitivity to TK inhibitors (TKIs). While mutational status is of great importance in determining response to TKIs, it