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Epidermal growth factor receptor mutations in lung cancers

โœ Scribed by Yasushi Yatabe; Tetsuya Mitsudomi


Book ID
115175780
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
486 KB
Volume
57
Category
Article
ISSN
1320-5463

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Somatic mutations of epidermal growth fa
โœ Hisayuki Shigematsu; Adi F. Gazdar ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 540 KB

Somatic mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers have generated enormous interest, because they predict for sensitivity to TK inhibitors (TKIs). While mutational status is of great importance in determining response to TKIs, it