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Epidermal growth factor receptor mutations and susceptibility to targeted therapy in lung cancer

โœ Scribed by Syed M. AHMED; Ravi SALGIA


Book ID
108964497
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
130 KB
Volume
11
Category
Article
ISSN
1323-7799

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Somatic mutations of epidermal growth fa
โœ Hisayuki Shigematsu; Adi F. Gazdar ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 540 KB

Somatic mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers have generated enormous interest, because they predict for sensitivity to TK inhibitors (TKIs). While mutational status is of great importance in determining response to TKIs, it