Targeting epidermal growth factor receptor in lung cancer
✍ Scribed by José Baselga; Joan Albanell
- Book ID
- 107546120
- Publisher
- Current Science Inc.
- Year
- 2002
- Tongue
- English
- Weight
- 604 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1523-3790
No coin nor oath required. For personal study only.
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## Abstract The epidermal growth factor receptor (EGFR) has been shown to be a promising therapeutic target in head and neck cancer. Cetuximab, a monoclonal antibody against EGFR, has been approved in the United States for use with radiotherapy for head and neck squamous cell carcinoma. However, th
Somatic mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers have generated enormous interest, because they predict for sensitivity to TK inhibitors (TKIs). While mutational status is of great importance in determining response to TKIs, it