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Epidermal growth factor receptor mutations in lung cancer

โœ Scribed by Sharma, Sreenath V.; Bell, Daphne W.; Settleman, Jeffrey; Haber, Daniel A.


Book ID
109947824
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
441 KB
Volume
7
Category
Article
ISSN
1474-1776

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Somatic mutations of epidermal growth fa
โœ Hisayuki Shigematsu; Adi F. Gazdar ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 540 KB

Somatic mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers have generated enormous interest, because they predict for sensitivity to TK inhibitors (TKIs). While mutational status is of great importance in determining response to TKIs, it