Association of epidermal growth factor receptor mutations in lung cancer with chemosensitivity to gefitinib in isolated cancer cells from Japanese patients
β Scribed by K. NAKATANI; M. TAKAO; J. NISHIOKA; K. YASUDA; K. NOMA; A. HAYASHI; H. WADA; T. NOBORI
- Book ID
- 108710425
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 88 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0961-5423
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## Abstract ## BACKGROUND. Because the investigation of epidermal growth factor receptor gene (__EGFR__) status as a predictor of gefitinib efficacy in Japanese patients has shown promise, the authors evaluated __EGFR__ mutations and gene amplification in biopsy specimens from Japanese patients wi
## Abstract We investigated the relationships between genetic factors and clinical outcome in Japanese nonβsmallβcell lung cancer (NSCLC) patients treated with gefitinib. Ninetyβeight NSCLC patients who had been treated with gefitinib, were screened for mutations in epidermal growth factor receptor
## Abstract Recently, mutations in the __epidermal growth factor receptor__ (__EGFR__) gene in nonsmall cell lung cancer (NSCLC) patients were reported to correlate with gefitinib response. Less than 30% of NSCLC patients are surgically resectable; however, molecular analysis has to rely on nonsurg