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Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer

✍ Scribed by Tetsuya Mitsudomi; Yasushi Yatabe


Book ID
108584006
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
987 KB
Volume
98
Category
Article
ISSN
1347-9032

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## Abstract ## BACKGROUND: Somatic mutations in the epidermal growth factor receptor (EGFR) kinase domain are associated with sensitivity to EGFR‐tyrosine kinase inhibitors (EGFR‐TKI) in patients with nonsmall cell lung cancer (NSCLC). ## METHODS: The authors tested the possibility that nucleoti