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IGFBP3 Promoter Methylation in Colorectal Cancer: Relationship with Microsatellite Instability, CpG Island Methylator Phenotype, p53

✍ Scribed by Kawasaki, Takako; Nosho, Katsuhiko; Ohnishi, Mutsuko; Suemoto, Yuko; Kirkner, Gregory J.; Fuchs, Charles S.; Ogino, Shuji


Book ID
125420419
Publisher
Neoplasia Press
Year
2007
Tongue
English
Weight
155 KB
Volume
9
Category
Article
ISSN
1522-8002

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## Abstract The CpG island methylator phenotype (CIMP) with widespread promoter CpG island methylation is a phenotype in colorectal cancer, associated with microsatellite instability (MSI) and __BRAF__ mutation. Genome‐wide hypomethylation may also play an important role in genomic instability. How