WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer
β Scribed by Kawasaki, Takako; Ohnishi, Mutsuko; Suemoto, Yuko; Kirkner, Gregory J; Liu, Zhiqian; Yamamoto, Hiroyuki; Loda, Massimo; Fuchs, Charles S; Ogino, Shuji
- Book ID
- 118675801
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 179 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0893-3952
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## Abstract Mucinous colorectal cancer (CRC) has been reported to have distinct clinicopathological and genetic characteristics. However, the incidence and the relationship among microsatellite instability (MSI), CpG island methylator phenotype (CIMP) and __BRAF__ and __KRAS__ mutations in mucinous
## Abstract The CpG island methylator phenotype (CIMP) with widespread promoter CpG island methylation is a phenotype in colorectal cancer, associated with microsatellite instability (MSI) and __BRAF__ mutation. Genomeβwide hypomethylation may also play an important role in genomic instability. How