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TGFBR2 mutation is correlated with CpG island methylator phenotype in microsatellite instability-high colorectal cancer

✍ Scribed by Shuji Ogino; Takako Kawasaki; Akiyo Ogawa; Gregory J. Kirkner; Massimo Loda; Charles S. Fuchs


Book ID
116534297
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
184 KB
Volume
38
Category
Article
ISSN
1532-8392

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## Abstract The CpG island methylator phenotype (CIMP) with widespread promoter CpG island methylation is a phenotype in colorectal cancer, associated with microsatellite instability (MSI) and __BRAF__ mutation. Genome‐wide hypomethylation may also play an important role in genomic instability. How