## Abstract The CpG island methylator phenotype (CIMP) with widespread promoter CpG island methylation is a phenotype in colorectal cancer, associated with microsatellite instability (MSI) and __BRAF__ mutation. Genomeβwide hypomethylation may also play an important role in genomic instability. How
SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
β Scribed by Nosho, Katsuhiko; Shima, Kaori; Irahara, Natsumi; Kure, Shoko; Firestein, Ron; Baba, Yoshifumi; Toyoda, Saori; Chen, Li; Hazra, Aditi; Giovannucci, Edward L
- Book ID
- 109887802
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 276 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0893-3952
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## Abstract Mucinous colorectal cancer (CRC) has been reported to have distinct clinicopathological and genetic characteristics. However, the incidence and the relationship among microsatellite instability (MSI), CpG island methylator phenotype (CIMP) and __BRAF__ and __KRAS__ mutations in mucinous
## Abstract The notion of a CpG island methylator phenotype (CIMP) was proposed to describe a subset of colorectal cancers (CRC) displaying frequent and concordant methylation of CpG islands located within gene promoter regions. Some workers have failed to observe associations between CIMP and spec