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Identification of the Tumor Metastasis Suppressor Nm23-H1/Nm23-R1 as a Constituent of the Centrosome

✍ Scribed by Dirk Roymans; Kris Vissenberg; Chris De Jonghe; Roel Willems; Gilbert Engler; Narimichi Kimura; Bert Grobben; Patrik Claes; Jean-Pierre Verbelen; Christine Van Broeckhoven; Herman Slegers

Book ID
115603879
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
327 KB
Volume
262
Category
Article
ISSN
0014-4827

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## Abstract __p53__, a tumor suppressor gene involved in the G1 cell cycle checkpoint, is also the most frequently mutated gene in human cancer. In addition, p53 modifies the ability of tumor cells to metastasize. The metastasis‐associated gene __Nm23‐H1__, which encodes an 18‐kDa nucleoside diphos