Plakoglobin interacts with and increases the protein levels of metastasis suppressor Nm23-H2 and regulates the expression of Nm23-H1
β Scribed by Aktary, Z; Chapman, K; Lam, L; Lo, A; Ji, C; Graham, K; Cook, L; Li, L; Mackey, J R; Pasdar, M
- Book ID
- 109971260
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 777 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0950-9232
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## Abstract __p53__, a tumor suppressor gene involved in the G1 cell cycle checkpoint, is also the most frequently mutated gene in human cancer. In addition, p53 modifies the ability of tumor cells to metastasize. The metastasisβassociated gene __Nm23βH1__, which encodes an 18βkDa nucleoside diphos
The nm23 gene is a potential metastasis-suppressor gene originally identified in a murine melanoma line. Several investigators have reported the probable inverse association of nm23 expression with disease prognosis and/or metastasis. Since there are now 2 known isotypes of human nm23, namely nm23-H