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Potential contributions of antimutator activity to the metastasis suppressor function of NM23-H1

✍ Scribed by David M. Kaetzel; Joseph R. McCorkle; Marian Novak; Mengmeng Yang; Stuart G. Jarrett

Book ID
106458865
Publisher
Springer
Year
2009
Tongue
English
Weight
226 KB
Volume
329
Category
Article
ISSN
0300-8177

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## Abstract __p53__, a tumor suppressor gene involved in the G1 cell cycle checkpoint, is also the most frequently mutated gene in human cancer. In addition, p53 modifies the ability of tumor cells to metastasize. The metastasis‐associated gene __Nm23‐H1__, which encodes an 18‐kDa nucleoside diphos