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Multiple mechanisms underlie metastasis suppressor function of NM23-H1 in melanoma

✍ Scribed by Marian Novak; Stuart G. Jarrett; Joseph R. McCorkle; Isabel Mellon; David M. Kaetzel

Book ID
105878102
Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
216 KB
Volume
384
Category
Article
ISSN
0028-1298

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## Abstract __p53__, a tumor suppressor gene involved in the G1 cell cycle checkpoint, is also the most frequently mutated gene in human cancer. In addition, p53 modifies the ability of tumor cells to metastasize. The metastasis‐associated gene __Nm23‐H1__, which encodes an 18‐kDa nucleoside diphos