𝔖 Bobbio Scriptorium
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Heparinized polyurethanes:In vitro andin vivo studies

✍ Scribed by Heyman, P. W. ;Cho, C. S. ;McRea, J. C. ;Olsen, D. B. ;Kim, S. W.

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
837 KB
Volume
19
Category
Article
ISSN
0021-9304

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✦ Synopsis

Abstract

Heparin immobilization chemistry using alkyl spacer arms was adapted to optimize yield on polyurethane (PU) surfaces. The resultant biological activity of immobilized heparin (HI) was examined in vitro and in vivo, and compared with a heparin releasing (HR) system. Immobilized heparin retained its ability to bind and inactivate thrombin and Factor Xa; nonspecific coagulation factor binding was insignificant. Such activity cannot be attributed to the leakage of improperly bound heparin. Immobilized heparin–polurethane catheters implanted in canine femoral and jugular veins for 1 h periods exhibited significant reduction in thrombus formation compared with untreated PU contralateral controls. Polyurethane catheters coated with a 9% heparin dispersion in PU (HR) system provided even greater improvement in antithrombogenicity.

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