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PAM-Microfabricated Polyurethane Scaffolds: in vivo and in vitro Preliminary Studies

✍ Scribed by Giovanni Vozzi; Alfonsina Rechichi; Francesca Dini; Claudia Salvadori; Federico Vozzi; Silvia Burchielli; Fabio Carlucci; Mario Arispici; Gianluca Ciardelli; Paolo Giusti; Arti Ahluwalia

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
432 KB
Volume
8
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Polymeric scaffolds were realised with linear degradable PU in the form of square, hexagonal and octagonal grids. They were characterised in terms of their mechanical properties. Analysis shows that the mechanical properties of the scaffolds depend on their geometries which are easily modulated using PAM. In vitro biological assays showed that PU promotes the adhesion and proliferation of fibroblast cells and that cell activities are better on PU scaffolds than on PU films. In vivo implantation of PU and PLGA scaffolds and PU films demonstrated that the scaffolds are completely resorbed after three months with a slight inflammatory response, while the PU film was still present after six months with an intense granulomatous reaction.

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