## Abstract Heparin immobilization chemistry using alkyl spacer arms was adapted to optimize yield on polyurethane (PU) surfaces. The resultant biological activity of immobilized heparin (HI) was examined __in vitro__ and __in vivo__, and compared with a heparin releasing (HR) system. Immobilized h
In vivo andin vitro aging of orthopedic aluminas
โ Scribed by Fahr, A. ;Brown, R. F. ;Day, D. E.
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 898 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0021-9304
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โฆ Synopsis
Abstract
The flexural strength, microstructure and relative Ca and Si concentration at the surface of two commercial orthopedic aluminas were studied before and after aging up to 52 weeks in simulated body fluids or in subcutaneous implantation in rodents. There was no significant reduction in flexural strength after aging, but there was evidence of Ca and Si dissolution from the external grain boundary surfaces, particularly for specimens aged in demineralized water. No change occurred in the Ca and Si concentrations within the specimen's bulk during either in vivo or in vitro aging.
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