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In vitro andin vivo studies of heparinized-collageno-elastic tubes

✍ Scribed by Senatore, Fred ;Shankar, Hariharan ;Chen, Jyh-Herng ;Avantsa, Srinivas ;Feola, Mario ;Posteraro, Robert ;Blackwell, Eric

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 902 KB
Volume: 24
Category: Article
ISSN: 0021-9304
DOI: 10.1002/jbm.820240711

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✦ Synopsis

Heparin was covalently coupled to collageno-elastic grafts (CET) derived from lamb carotid arteries, by u s i n g t h e crosslinking agent 1-ethyl-3 (3-dimethylaminopropyl) carbodiimide (EDC). The collagenous grafts were pretreated with various aminating agents in order to enhance the number of available binding sites on the collagen surface. By varying the EDC/heparin weight ratio, the pH of the immobilization media, and the pretreatment agent, a global search pattern maximized heparin loading at 3.90 * 0.36 USP heparin/cm* collagenous graft surface when the EDC/heparin ratio was 2:l at a pH of 1.5 with 1 M hydroxylamine sulfate as the pretreatment agent. Heparinized CETs were superior to nonheparinized CETs by exhibiting b o t h e n h a n c e d antiplatelet activity in using an in vitro differential recirculation reactor with chromium-51 tagged platelets and enhanced patency when interposed in canine carotid arteries. Both antiplatelet activity and patency duration for heparinized CETs were independent of heparin loading.

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