A histological study of the early stages of cutaneous wound healing in lizards inin vivo andin vitro
✍ Scribed by Maderson, P. F. A. ;Roth, S. I.
- Publisher
- John Wiley and Sons
- Year
- 1972
- Tongue
- English
- Weight
- 991 KB
- Volume
- 180
- Category
- Article
- ISSN
- 0022-104X
No coin nor oath required. For personal study only.
✦ Synopsis
The responses of the skin to wounding from six hours to ten days have been studied histologically i n a variety of lizard species. Whatever the size of the initial wound, all aspects of cutaneous structure, i.e., general scale architecture, epidermal cell activity, and epidermal specializations, are disrupted by a sequence of cellular events quite distinct from those described i n other vertebrates. The epidermis on either side of the incision dies along a variable length, and epithelial migration occurs along a prepared hypercellular path through the dermis where the normal collagen fibers are destroyed. A segment of apparently physically undamaged tissue is discarded from the body surface and the subjacent "wound epidermis" undergoes rapid cell proliferation and maturation leading to the formation of a hyperplastic cornified tissue whose cells resemble the normal a-layer, but which shows no indication of the typical epidermal generation structure.