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Germline alterations in the 53BP1 gene in breast and ovarian cancer families

โœ Scribed by Katrin Rapakko; Katri Heikkinen; Sanna-Maria Karppinen; Hannele Erkko; Robert Winqvist


Book ID
116334147
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
85 KB
Volume
245
Category
Article
ISSN
0304-3835

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The two major hereditary breast/ovarian cancer predisposition tumor suppressor genes, BRCA1 and BRCA2 that perform apparently generic cellular functions nonetheless cause tissue-specific syndromes in the human population when they are altered, or mutated in the germline. However, little is known abo