The two major hereditary breast/ovarian cancer predisposition tumor suppressor genes, BRCA1 and BRCA2 that perform apparently generic cellular functions nonetheless cause tissue-specific syndromes in the human population when they are altered, or mutated in the germline. However, little is known abo
177 Novel germline mutations in BRCA2 gene among breast and breast-ovarian cancer families from Poland
β Scribed by A. Balabas; E. Skasko; D. Nowakowska; A. Niwinska; P. Blecharz; T. Pienkowski
- Book ID
- 119601194
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 65 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1359-6349
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## Communicated by Mark H. Paalman Germline mutations in breast cancer susceptibility genes, BRCA1 and BRCA2, are responsible for a substantial proportion of high-risk breast and breast/ovarian cancer families. To characterize the spectrum of BRCA1 and BRCA2 mutations, we screened Czech families w
Germline mutations in the BRCA1 and BRCA2 genes account for the majority of high-risk breast/ovarian cancer families, depending on the population studied. Previously, BRCA1 mutations were described in women from Western Poland. To further characterize the spectrum of BRCA1 mutations and the impact o
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