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Germline mutations of TP53 and BRCA2 genes in breast cancer/sarcoma families

โœ Scribed by Siranoush Manoukian; Bernard Peissel; Valeria Pensotti; Monica Barile; Laura Cortesi; Silvia Stacchiotti; Monica Terenziani; Floriana Barbera; Graziella Pasquini; Simona Frigerio; Marco A. Pierotti; Paolo Radice; Gabriella Della-Torre


Book ID
116429186
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
207 KB
Volume
43
Category
Article
ISSN
0959-8049

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Germline mutations of BRCA2 were examined in 20 Japanese breast cancer families without BRCA1 mutations, including one demonstrating cancer development in a male. Three different mutations, resulting in truncation of the BRCA2 protein, were detected in 3 different families. They were 9474insA (exon