Germline mutations of BRCA2 were examined in 20 Japanese breast cancer families without BRCA1 mutations, including one demonstrating cancer development in a male. Three different mutations, resulting in truncation of the BRCA2 protein, were detected in 3 different families. They were 9474insA (exon
BRCA2 germline mutations in Swedish breast cancer families
✍ Scribed by Chen, Jindong; Hedman, Moraima Zelada; Arver, Brita Wasteson; Sigurdsson, Stefan; Eyfjörd, Jorunn Erla; Lindblom, Annika
- Book ID
- 110024679
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 179 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1018-4813
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Germline mutation analysis of BRCA1 gene has demonstrated significant allelic heterogeneity. These differences represent historical influences of migration, population structure and geographic or cultural isolation. To date, there have been no reports of Indian families with mutations in BRCA1. We h
Germline mutations in the BRCA2 gene have been shown to be associated with familial female and male breast cancer. Mutations occur throughout the entire coding region of the gene, and there is considerable ethnic and geographical diversity in the deleterious mutations detected in different populatio