Germline mutations of BRCA2 were examined in 20 Japanese breast cancer families without BRCA1 mutations, including one demonstrating cancer development in a male. Three different mutations, resulting in truncation of the BRCA2 protein, were detected in 3 different families. They were 9474insA (exon
BRCA1 andBRCA2 germline mutations in Japanese with hereditary breast cancer families
โ Scribed by Takashi Fukutomi; Toshikazu Ushijima; Rie Inoue; Sadako Akashitanaka; Takeshi Nanasawa; Hitoshi Tsuda
- Publisher
- Springer Japan
- Year
- 1997
- Tongue
- English
- Weight
- 227 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1340-6868
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๐ SIMILAR VOLUMES
Germline mutation analysis of BRCA1 gene has demonstrated significant allelic heterogeneity. These differences represent historical influences of migration, population structure and geographic or cultural isolation. To date, there have been no reports of Indian families with mutations in BRCA1. We h
Germline mutations in the BRCA2 gene have been shown to be associated with familial female and male breast cancer. Mutations occur throughout the entire coding region of the gene, and there is considerable ethnic and geographical diversity in the deleterious mutations detected in different populatio