In order to evaluate the role of BRCA1 and BRCA2 germline mutations in Korean patients with sporadic breast cancer, 97 patients with sporadic breast cancer were analyzed for mutations in the BRCA1 and BRCA2 coding regions, by using a combination of fluorescent-conformation sensitive gel electrophore
BRCA1andBRCA2germline mutations in Korean ovarian cancer patients
β Scribed by Myong Cheol Lim; Sokbom Kang; Sang-Soo Seo; Sun-Young Kong; Bo-Yon Lee; Seon-Kyung Lee; Sang-Yoon Park
- Publisher
- Springer-Verlag
- Year
- 2009
- Tongue
- English
- Weight
- 334 KB
- Volume
- 135
- Category
- Article
- ISSN
- 1432-1335
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Germline mutations in the BRCA1 and BRCA2 genes are responsible for the predisposition and development of familial breast and/or ovarian cancer. Most mutations of BRCA1 and BRCA2 associated with breast and/or ovarian cancer result in truncated proteins. To investigate the presence of BRCA1 and BRCA2
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