In order to evaluate the role of BRCA1 and BRCA2 germline mutations in Korean patients with sporadic breast cancer, 97 patients with sporadic breast cancer were analyzed for mutations in the BRCA1 and BRCA2 coding regions, by using a combination of fluorescent-conformation sensitive gel electrophore
Characteristics of double heterozygosity for BRCA1 and BRCA2 germline mutations in Korean breast cancer patients
β Scribed by Jae Myoung Noh; Doo Ho Choi; Seok Jin Nam; Jeong Eon Lee; Jong Won Kim; Sung-Won Kim; Eunyoung Kang; Min Hyuk Lee; Sei Hyun Ahn; Ku Sang Kim; Sue K. Park; Bruce G. Haffty; Korea Breast Cancer Study Group
- Publisher
- Springer US
- Year
- 2011
- Tongue
- English
- Weight
- 278 KB
- Volume
- 131
- Category
- Article
- ISSN
- 0167-6806
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Germline mutations in the BRCA1 and BRCA2 genes are responsible for the predisposition and development of familial breast and/or ovarian cancer. Most mutations of BRCA1 and BRCA2 associated with breast and/or ovarian cancer result in truncated proteins. To investigate the presence of BRCA1 and BRCA2
In this study we genotyped Turkish breast/ovarian cancer patients for BRCA1/BRCA2 mutations: protein truncation test (PTT) for exon 11 BRCA1 of and, multiplex PCR and denaturing gradient gel electrophoresis (DGGE) for BRCA2, complemented by DNA sequencing. In addition, a modified restriction assay w
## Abstract Our aim was to estimate the prevalence of mutations in the __BRCA1__ and __BRCA2__ genes among unselected incident cases of breast cancer in young women. We identified 158 incident breast cancer cases diagnosed before age 46 years in predefined geographic areas in Girona and Tarragona,