Analysis of BRCA1, TP53, and TSG101 germline mutations in German breast and/or ovarian cancer families
β Scribed by Vera Balz; Hans Bernd Prisack; Henning Bier; Hans Bojar
- Book ID
- 114135407
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 160 KB
- Volume
- 138
- Category
- Article
- ISSN
- 0165-4608
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π SIMILAR VOLUMES
Germline mutations in the BRCA1 and BRCA2 genes are responsible for the predisposition and development of familial breast and/or ovarian cancer. Most mutations of BRCA1 and BRCA2 associated with breast and/or ovarian cancer result in truncated proteins. To investigate the presence of BRCA1 and BRCA2
Women harboring BRCA1 germline mutations carry an 85% lifetime risk of developing breast cancer and a 63% risk of ovarian cancer. In this first systematic study of familial breast and/or ovarian cancer in Germany we investigated 29 families for germline mutations in the BRCA1 gene. We identified mut