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Germline alterations in the CLSPN gene in breast cancer families

✍ Scribed by Hannele Erkko; Katri Pylkäs; Sanna-Maria Karppinen; Robert Winqvist


Book ID
116334581
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
113 KB
Volume
261
Category
Article
ISSN
0304-3835

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Germline mutations of BRCA2 were examined in 20 Japanese breast cancer families without BRCA1 mutations, including one demonstrating cancer development in a male. Three different mutations, resulting in truncation of the BRCA2 protein, were detected in 3 different families. They were 9474insA (exon