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Germline alterations in the CDH1 gene in familial gastric cancer in the Japanese population

✍ Scribed by Hidetaka Yamada; Kazuya Shinmura; Hiroaki Ito; Masako Kasami; Naomi Sasaki; Hideyuki Shima; Masami Ikeda; Hong Tao; Masanori Goto; Takachika Ozawa; Toshihiro Tsuneyoshi; Fumihiko Tanioka; Haruhiko Sugimura


Book ID
108589134
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
485 KB
Volume
102
Category
Article
ISSN
1347-9032

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Hereditary diffuse gastric cancer (HDGC) is a recently defined cancer syndrome caused by inactivating, heterozygous germline mutations in the gene for the cell-to-cell adhesion protein E-cadherin (CDH1). Here, we describe the search for CDH1 mutations in 10 newly identified gastric cancer families.