Expeditious Solid-Phase Synthesis of Pyrazoledicarboxylic Acid Derivatives by Functionalization of Resin-Bound Cyanoformate
โ Scribed by Carlo F. Morelli; Alberto Saladino; Giovanna Speranza; Paolo Manitto
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 137 KB
- Volume
- 2005
- Category
- Article
- ISSN
- 1434-193X
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๐ SIMILAR VOLUMES
A new method for the solid phase synthesis of benzothiazoles and 2-arylamino-3-carboxyl-4-hydroxy-5-arylthiophenes is described. Resin bound cyclic malonic acid ester was reacted with aryl isothiocyanates and then with bromine or a-bromoketones, followed by treatment with perchloric acid or sodium m
Resin-bound cyclobutanone iminium salts, prepared on the solid-phase using the [2+2]-keteneiminium olefin cycloaddition reaction, have been transformed into a number of distinct structural classes including ฮณ-lactams, ฮณ-lactones, cyclobutylamines and cyclobutanols.
Resin-bound N-acylated amino acid aldehydes iv were converted in a single step to a-hydroxy phosphonates vii (Pudovik reaction) and in six-steps to hydroxystatine amides viii, demonstrating the utility of intermediates iv for constructing multiple aspartic acid transition-state isosteres.
The first synthesis of N-aceOd-wamina acids by radical addition on solid support to commercialy available 2-acetamidoacrylic acid ~tng the merctey method is described The reaction proceeds in acceptable chemical efficiency (49-60~) depending on the nature of the mercury halide agent. Cleavage by mil