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Solid-phase synthesis of α-amino acids by radical addition to adehydroalanine derivative

✍ Scribed by Anne-Marie Yim; Yves Vidal; Philippe Viallefont; Jean Martinez

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
210 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

The first synthesis of N-aceOd-wamina acids by radical addition on solid support to commercialy available 2-acetamidoacrylic acid ~tng the merctey method is described The reaction proceeds in acceptable chemical efficiency (49-60~) depending on the nature of the mercury halide agent. Cleavage by mild acid treatment released the prodact from the solid support in excellent purity.

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