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Rapid solid phase synthesis of α-amino acids

✍ Scribed by Mireille Barbaste; Valérie Rolland-Fulcrand; Marie-Louise Roumestant; Philippe Viallefont; Jean Martinez

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
201 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

A solid phase synthetic method for amino acids is developed. The N-acetyl-dehydroalanine is quantitatively bound to Wang resin by the Mitsunobu method. Then a Michael addition is achieved on the double bond with different nucleophiles. Non proteinic N-acetyl-ct-amino acids are obtained after cleavage from the resin by mild acid treatment (Scheme 1).

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