A combinatorial method for the solid phase synthesis of α-amino phosphonates and phosphonic acids
✍ Scribed by Chengzhi Zhang; Adnan M.M Mjalli
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 219 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
The enantioselective synthesis of a-aminoand a-hydroxy phosphonates by catalytic processes has attracted considerable interest in the last few years, not least because of the pharmaceutical interest in such compounds. This article contains a compilation of the asymmetric synthesis methods developed
Resin-bound N-acylated amino acid aldehydes iv were converted in a single step to a-hydroxy phosphonates vii (Pudovik reaction) and in six-steps to hydroxystatine amides viii, demonstrating the utility of intermediates iv for constructing multiple aspartic acid transition-state isosteres.