Combinatorial method for the synthesis of α-hydroxy phosphonates on Wang resin
✍ Scribed by Xiaodong Cao; Adnan M.M Mjalli
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 164 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The enantioselective synthesis of a-aminoand a-hydroxy phosphonates by catalytic processes has attracted considerable interest in the last few years, not least because of the pharmaceutical interest in such compounds. This article contains a compilation of the asymmetric synthesis methods developed
A bstract: LaLi3tris(binaphthoxide) catalyst (LLB), which is prepared from LaCI 3 • 7H20 (1 mol equiv), (R)-or (S)-BINOL dilithium salt (2.7 mol equiv), and NaO-t-Bu (0.3 mol equiv), is effective for the hydrophosphonylation of various aldehydes to give desired et-hy~'oxyphosphonates in up to 95% ee