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Enantioselective synthesis of α-hydroxy phosphonates using the LaLi3tris(binaphthoxide) catalyst (LLB), prepared by an improved method

✍ Scribed by Hiroaki Sasai; Masahiro Bougauchi; Takayoshi Arai; Masakatsu Shibasaki

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 264 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)00437-1

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✦ Synopsis

A bstract: LaLi3tris(binaphthoxide) catalyst (LLB), which is prepared from LaCI 3 • 7H20 (1 mol equiv), (R)-or (S)-BINOL dilithium salt (2.7 mol equiv), and NaO-t-Bu (0.3 mol equiv), is effective for the hydrophosphonylation of various aldehydes to give desired et-hy~'oxyphosphonates in up to 95% ee (88% yield). It is also noteworthy that with slow addition of the aldehydes the enantiomeric excesses of

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ChemInform Abstract: Enantioselective Synthesis of α-Hydroxy Phosphonates Using the LaLi3tris(binaphthoxide) Catalyst (LLB), Prepared by an Improved Method.

✍ H. SASAI; M. BOUGAUCHI; T. ARAI; M. SHIBASAKI 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 1 views