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Solid Phase Synthesis of 2-Substituted1, 3-Oxazin-6-ones Using Resin-bound Cyclic Malonic Acid Ester

โœ Scribed by Zhan-Xiang Liu; Xiu-Xiu Ruan; Xian Huang


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
242 KB
Volume
22
Category
Article
ISSN
0256-7660

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A new method for the solid phase synthesis of benzothiazoles and 2-arylamino-3-carboxyl-4-hydroxy-5-arylthiophenes is described. Resin bound cyclic malonic acid ester was reacted with aryl isothiocyanates and then with bromine or a-bromoketones, followed by treatment with perchloric acid or sodium m

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