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Preparation of a resin-bound cyclic malonic ester and a facile solid-phase synthesis of 4(1H)quinolones

✍ Scribed by Xian Huang; Zhanxiang Liu

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 61 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)01622-7

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✦ Synopsis

A resin-bound cyclic malonic ester has been prepared on Merrifield resin. Reaction of the cyclic malonic ester with triethyl orthoformate and subsequent substitution by an arylamine afforded arylaminomethylene cyclic malonic ester preloaded resin. A series of 4(1H)quinolones were prepared by thermal cyclization in moderate yields and high purity.

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