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Solid phase synthesis of benzothiazole and thiophene derivatives based on resin-bound cyclic malonic acid ester

โœ Scribed by Xian Huang; Jing Tang

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
308 KB
Volume
59
Category
Article
ISSN
0040-4020

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โœฆ Synopsis

A new method for the solid phase synthesis of benzothiazoles and 2-arylamino-3-carboxyl-4-hydroxy-5-arylthiophenes is described. Resin bound cyclic malonic acid ester was reacted with aryl isothiocyanates and then with bromine or a-bromoketones, followed by treatment with perchloric acid or sodium methoxide to afford substituted 2-methylbenzothiazoles or 2-arylamino-3-carboxyl-4-hydroxy-5-arylthiophenes, respectively, in high yields and purities.

๐Ÿ“œ SIMILAR VOLUMES

Preparation of a resin-bound cyclic malo
Preparation of a resin-bound cyclic malonic ester and a facile solid-phase synthesis of 4(1H)quinolones
โœ Xian Huang; Zhanxiang Liu ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 61 KB

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